Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection.

Despite the small sample size and varying days of observation, we detected highly significant differences between mock and trivalent immunized animals for days with genital lesion in both experiments. 3) Vaginal shedding of HSV-1 DNA was monitored over different time periods post-infection.

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