Association between adjuvant chemotherapy and survival in patients with rectal cancer and pathological complete response after neoadjuvant chemoradiotherapy and resection.

26 A long-term analysis of 566 pCR patients from the Gastro-Intestinal Working Group of the Italian Association of Radiation Oncology database found that ACT was even associated with a worse outcome (borderline significance). 27 Therefore, the efficacy of ACT remains controversial in patients who achieve pCR after nCRT. 28 The objective of this study was to assess whether ACT treatment would have any survival outcome benefit in LARC patients who achieved pCR after nCRT treatment and TME surgery.

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