The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors Are Associated with Interleukin-6.

Diagnostics (Basel) · 2020 · PMC7554941 · PMID 32858974

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Moreover, the combination of IL-6 with endomorphin 2 and MOR yielded a highly significant discrimination of NRTT from PRTT indicating that upregulation of the immune-EOS axis is associated with the pathophysiology of a non-response to treatment.

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