Barely Significant
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In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins.

Int J Mol Sci · 2020 · PMC7555035 · PMID 32967310

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highly significantno p-value reported
Furthermore, platelet PDE activity after coffee consumption by humans was tested, since caffeine is a major constituent of coffee, and the in vivo results revealed highly significant PDE inhibition after coffee intervention despite indirect dependence on the caffeine content of coffee.

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