Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells.

Antioxidants (Basel) · 2020 · PMC7555107 · PMID 32859013

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not yet significantno p-value reported

In the meanwhile clinical studies already indicate a potent impact of anti-Properdin antibodies in AMD patients: Intravitreal injection of 10 mg anti-Properdin antibodies reduced the lesion size in GA patients by ~16% compared to sham treated patients in phase 2 studies (not yet significant, NCT02515942 ).

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