We have added a line to the text: “Although utilising the clinical information from two previous expensive large animal pilot studies meant accepting low numbers of animals, it is in keeping with the reduction and refinement principle of 3R’s in research.[29]” lines 246-248 Moreover, although a lack of study power was possible, the result of the test of agreement between the ratings was in both cases very highly significant, indicating that concerns about a false negative conclusion are unfounded. - In the experimental designs: Why did you choose the OP dimethoate?
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Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model.
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