ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.

Correlations remained highly significant even after adjusting for age, gender and ejection fraction using linear regression analysis (standardized coefficient = 0.461, p < 0.001 for ZMPSTE24mRNA vs. progerin mRNA, and stand. coeff. = 0.747, p < 0.001 for laminA/C mRNA vs. progerin mRNA).

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In line with this assumption, we could not find a significant correlation of lamin A/C mRNA with ZMPSTE24 expression, although there was a slight trend and a priori it would be assumed, that increased lamin A/C levels may influence ZMPSTE24 expression levels.

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