Tetravalent Immunogen Assembled from Conserved Regions of HIV-1 and Delivered as mRNA Demonstrates Potent Preclinical T-Cell Immunogenicity and Breadth.

While significant differences between groups were only rarely reached, there was an overall trend of a direct correlation between the magnitude of vaccine responses and valency of the vaccine cocktail both for individual epitopes ( Figure 2 b) and the overall ‘global’ response, which reached median (range) 11,821 (10,268–13,506) SFU/10 6 HIVconsvM-specific splenocytes ( Figure 2 c) keeping in mind that the absolute mRNA dose increased with each component added.

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