Although we did not see any significant differences in in vivo osteoblast activity among the experimental groups, both NRF2 KO and DKO mice showed a decreasing trend of in vivo osteoblast activity compared to WT mice.
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NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion.
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Histomorphometric analysis of the hind paw tarsal bones revealed an increasing trend of ES/BS, Oc.S/BS, and N.Oc./BS in NRF2 KO mice compared to those of WT mice ( Figure 7 C,D).