IFNα-induced apoptosis in the B lymphoma cell line Daudi requires c-Jun N-terminal kinase 1 (JNK1) [ 101 ], and it may be significant that IFNγ + IL-1β also induce apoptosis and promote activation of IRE1α and JNK1 in EndoC-βH1 cells [ 92 , 102 ].
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Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection.
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