Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis.

3 d, the positive areas of CK7 and CK19 were increased significantly in the BDL and BMSC Numb -KD groups compared to that in Sham ( P < 0.01) and BMSC NC ( P < 0.01) groups, respectively, while the positive area of CK19 was decreased significantly in the HQD and the HQD plus BMSC Numb -KD groups compared to that in the BDL ( P < 0.01) and BMSC Numb -KD ( P < 0.05) groups, respectively; the expression of CK7 were decreased significantly in the HQD group compared with the BDL ( P < 0.01), and CK7 showed a decreasing trend in the HQD plus BMSC Numb -KD group compared to that in the BMSC Numb -KD group, with no significant difference ( P > 0.05).

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