There were generally highly significant differences between subjects with CC, CT, and TT alleles in the sequence divergence of their infecting strains from a reconstructed ancestral sequence of each genotype, both at nonsynonymous sites and synonymous sites for all three genotypes ( Fig. 7 ).
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Impact of virus subtype and host <i>IFNL4</i> genotype on large-scale RNA structure formation in the genome of hepatitis C virus.
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