It is known that NRAS‐mutant cancer cell lines rely on signalling through CRAF ( RAF1 ) and SHOC2 (Dumaz et al , 2006 ; Kaplan et al , 2012 ; Jones et al , 2019 ) and we could identify this association as a highly significant association in CEN‐tools (Fig 3 A).
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CEN-tools: an integrative platform to identify the contexts of essential genes.
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