Prostate cancer tumour control probability modelling for external beam radiotherapy based on multi-parametric MRI-GTV definition.

Radiat Oncol · 2020 · PMC7574270 · PMID 33081804

Europe PMC DOI

hedged sentences

0.0425

closest p · 0.8× alpha

0.0482

boldest claim

The sentences

marginal significancep = 0.0425actually significant

When using a fixed α/β value of 1.6 Gy for both targets, the model fitting (HL-test: p = 0.7960, X 2 = 4.63) shows the same results for a high significance for Gleason score ( p = 0.0025) and gEUD 2Gy in prostate gland ( p = 0.0021) and marginal significance for the volume of mpMRI-GTV ( p = 0.0425) (Additional file 1 : Section 6).

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marginally significantp = 0.0482actually significant

When comparing the gEUD 2Gy values for the two response groups (BR and BC) and the two target types, prostate gland and GTV, only for the prostate gland, a marginally significant lower gEUD 2Gy value in the BR group could be demonstrated ( p = 0.0482, Fig. 2 ).

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marginally insignificantno p-value reported

Conversely, the gEUD2Gy for prostate gland ( p = 0.0633) and the volume of mpMRI-GTV ( p = 0.0775) has been shown to be marginally insignificant (Additional file 1 : Section 6).

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