Changes in Cigarette Consumption With Reduced Nicotine Content Cigarettes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage: 3 Randomized Clinical Trials.

Effects on QSU Factor 2 (ie, anticipated relief from negative affect) varied by dose and time (Cohen d = 0.12; P < .001) (eFigure 5 in Supplement 2 ), with decreasing linear trends across weeks at 0.4 mg/g (−0.02 [95% CI, −0.03 to −0.01]) and 2.4 mg/g (−0.01 [95% CI, −0.02 to −0.01]) doses and an increasing trend at the 15.8 mg/g dose (0.02 [95% CI, 0.01 to 0.03]).

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