Cognitive phenotypes 1 month after ICU discharge in mechanically ventilated patients: a prospective observational cohort study.

Age (OR 1.05; 95% CI 1.00–1.01; p = 0.048), gender (OR 2.81; 95% CI 1.01–7.84; p = 0.048) and cognitive reserve (OR 0.37; 95% CI 0.16–0.83; p = 0.016) resulted statically significant, while days with opioids ratio presented a trend toward significance (OR 0.17; 95% CI 0.03–1.08; p = 0.061).

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Although the ratio between days with opioids and days of ICU stay only reached a trend towards significance in the exploratory analysis, opioid treatment was the only precipitating factor that could be related to cognitive decline in our sample.

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