Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.

Flow cytometric analysis of blood immune cells demonstrated a significant decrease in CSF1R + monocytes after CSF1R antibody treatment, which, although a slight trend toward a reduction in cell number can be observed, was not significant after IL-34 antibody administration ( Figure 2E , for gating strategy see Supplementary Figure 1 ).

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