Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic: Perspective from a European country.

This trial accrued 11,303 patients between March and June 2020 and, in this short period of time, was already able to show a highly significant benefit of dexamethasone on mortality [ 114 ], which immediately led to the use of glucocorticoids as standard of care for hospitalised COVID-19 patients. 10.2 Methodological errors Methodological issues have arisen in a number of studies dedicated to prediction models for diagnosis and prognosis (mortality risk, progression to severe disease, length of hospital stay) of patients with COVID-19.

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