Antimicrobial Hypochlorous Wound Irrigation Solutions Demonstrate Lower Anti-biofilm Efficacy Against Bacterial Biofilm in a Complex <i>in-vitro</i> Human Plasma Biofilm Model (hpBIOM) Than Common Wound Antimicrobials.

wound infection biofilm antimicrobial antiseptic hypochlorous acid human plasma biofilm model wound irrigation chronic wound internal grant program of the Faculty of Health at Witten/Herdecke University, Germany IFF2018-61 German “Initiative Chronische Wunde e.V.” (ICW e.V.) Both reference substances, OCT/PE and PHMB-based irrigation solution, achieved a highly significant reduction of P. aeruginosa (4.77 ± 1.41 and 5.25 ± 0.93 log 10 steps, respectively; p < 0.0001), S. aureus (6.18 ± 0.00 and 4.82 ± 1.36 log 10 steps; p < 0.0001), and MRSA (both 6.18 ± 0.00 log 10 steps; p < 0.0001) within 30 min of exposure ( Figures 2A – C ).

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