There is a trend towards significance in the difference in the growth rates of tumors treated with rhTRAIL IV alone and tumors treated with a combination of 100 mg/kg ONC201 orally and rhTRAIL IV ( p = 0.27, Figure 5A ; p = 0.11, Figure 5B ).
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TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic.
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