After conducting GWAS on the 4505 isolates with associated azithromycin MICs, we identified highly significant unitigs (i.e., genetic variants generated from de novo assemblies) mapping to the 23S rRNA, associated with increased resistance, and to the efflux pump gene mtrC , associated with increased susceptibility and cervical infections 7 .
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Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.
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