New Pathways of Mutational Change in SARS-CoV-2 Proteomes Involve Regions of Intrinsic Disorder Important for Virus Replication and Release.

34 However, the analysis revealed highly significant intrinsic disorder (scores ⩾ 0.5) were present in the C-terminal and to a lesser degree in the N-terminal regions of the molecule, supporting the hypothesis that these regions are not resolved in the cryo-EM density map because of disorder.

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