All-Cause Mortality and Cardiovascular Death between Statins and Omega-3 Supplementation: A Meta-Analysis and Network Meta-Analysis from 55 Randomized Controlled Trials.

In terms of CVD death, the results from the REDUCE-IT [ 40 ], ASCEND [ 24 ], and GISSI-P [ 40 ] trials, which accounted for 31.4% of the sample size, were only borderline significant, with RRs and 95% CIs of 0.82 (0.67–0.99), 0.82 (0.67–0.99), and 0.84 (0.72–0.97), respectively ( Figure A2 and Figure A4 ).

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Overall, statin use showed a statistically significant risk reduction for all-cause mortality and CVD death, with RRs (95% CIs) 0.90 (0.86–0.94) and 0.86 (0.80–0.92), respectively, whereas the findings for omega-3 supplementation were of borderline significance, with RRs (95% CIs) of 0.97 (0.94–1.01) and 0.92 (0.87–0.98), respectively.

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