The results of the IPA analysis revealed highly significant overlap of 207 canonical pathways associated with the DEGs in the SK-MES-1 cell line, including the ‘mitotic roles of polo-like kinase’, ‘protein ubiquitination pathway’, ‘inhibition of matrix metalloproteases’ and ‘cell cycle: G2/M DNA damage checkpoint regulation’.
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Mechanism of intrinsic resistance of lung squamous cell carcinoma to epithelial growth factor receptor-tyrosine kinase inhibitors revealed by high-throughput RNA interference screening.
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