Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma.

Highly significant positive correlations were observed between serum GDF-15 and markers of glomerular filtration: serum creatinine ( R = 0.57; p < 0.001) and serum cystatin C ( R = 0.70; p < 0.001; Figure 4(b) ).

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GDF-15 (ln-transformed) was not significantly associated with overall survival, neither in simple analysis nor after adjustment for these predictors; however, the association was close to being statistically significant ( Table 5 ).

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However, these differences were marginally significant, which may also reflect an insufficient sample among subgroups.

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