highly significantp = 0.009
There was no significant negative correlation between the change in the global methylation degree of CpG1 and gene expression ( r = −0.462, p = 0.357), of which the change in the degree of methylation of 17 CpG sites was negatively correlated with gene expression, and the mC-20 site showed a highly significant negative correlation with gene expression ( r = −0.920, p = 0.009).