The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials.

Despite the overall reduction in morphine use, subgroup analysis demonstrated that administration of vitamin C through the oral route only showed borderline significance in this aspect ( p = 0.05).

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placebo group, n = 88) [ 23 , 24 ] were available for analysis, which demonstrated a highly significant increase in circulating vitamin C concentration in patients with perioperative vitamin C supplementation compared with that in those without (WMD = 4.91 mg/L, 95% CI 2.85 to 6.97, p < 0.00001; I 2 = 65%) ( Figure 14 ). 4.

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