Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells.

As shown in Figure 5 , in control cells, acute stimulation with 10 −9 M insulin for 5 min induced a significant increase in tyrosine phosphorylation of the IR β subunit (p-IR-β), whereas in palmitate pre-exposed cells, the insulin effect on IR phosphorylation was abrogated; moreover, in palmitate pretreated cells, the contemporaneous presence of DCI (0.1 and 1 mM) markedly increased insulin-induced IR-β phosphorylation, with an increasing trend with respect to cells treated only with palmitate in the absence of DCI ( Figure 5 A).

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