Further studies highlighted the significant association of hMSH3 mutations with the development of leukoplakia and its progression to OSCC and that a decreasing trend in MMR expression can be detected when testing non-dysplastic samples and oral preneoplastic lesions with progressively increasing severity [ 61 , 65 ].
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The Mismatch Repair System (MMR) in Head and Neck Carcinogenesis and Its Role in Modulating the Response to Immunotherapy: A Critical Review.
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