Changes in plasma bile acids are associated with gallbladder stones and polyps.

Moreover, the median ratio of total conjugated to unconjugated primary BAs ([GCA + TCA + GCDCA + TCDCA]/[CA + CDCA]) was 0.38 for healthy controls, 0.60 for cholecystolithiasis patients, and 0.51 for the non-neoplastic polyp group, and difference were highly significant ( p < 0.05) for cholecystolithiasis versus healthy control groups (Fig. 3 e).

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