Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes.

All CpGs that were highly significant [−log( P- value) > 50] were negatively correlated with the expression of their corresponding gene, and many of them were recurrent in several tumor types, namely CpGs in TDRD1 ( n = 16 tumor types), RNF17 ( n = 13 tumor types), SP140L ( n = 5 tumor types), and STK31 ( n = 3 tumor types) ( Fig. 3 D).

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