AAV-mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response.

Mol Oncol · 2020 · PMC7607180 · PMID 32813937

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a decreasing trendno p-value reported

Though not significant, the proportion of CD4 + T cells had a decreasing trend in AAV‐DNase I‐treated mice.

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