Intelligent microbial cell factory with genetic pH shooting (GPS) for cell self-responsive base/acid regulation.

Microb Cell Fact · 2020 · PMC7607686 · PMID 33138821

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not quite significantno p-value reported

But the superiority was not quite significant in scale-up fermentation because the pH changed dramatically during the first 12 h and lots of acid or alkali were needed to adjust the pH (Fig. 8 c).

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