With the growing understanding of the function of telomerase in telomere protection in addition to telomere synthesis ( Cesare et al., 2013 ; Perera et al., 2019 ; Sarthy and Baumann, 2010 ), mechanisms of telomerase regulation shown here, implicating potential crosstalk with telomeres, might be significant.
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Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction.
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