Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.

Nat Genet · 2021 · PMC7611829 · PMID 34556857

Europe PMC DOI

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highly significantp =1.28e-07actually significant

Importantly, comparing genes differentially expressed in NPM1c/FLT3 -ITD mutated human AML 19 with our differentially expressed genes between DM and WT HSPC, we could demonstrate a highly significant overlap with 27% up- (119/441, p =1.28e-07) and 15% (74/503, p =1.27e-07) of downregulated human genes also evident in our dataset Figure 1h ).

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