DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition.

Consequently, there was a highly significant underrepresentation of such differentiation profiles such as the VERHAAK_GLIOBLASTOMA_PRONEURAL signature in the clones (nominal P = 0.000446; Fig. 4C ), along with an enrichment of mesenchymal gene sets such as HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION (nominal P = 0.000227; Fig. 4D ).

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