Second, our study had excellent statistical power, yielding highly significant MR associations for IFNAR2 ( P =9.8×10 -11 ), increasing confidence in the validity of the much weaker signals for IFNAR2 reported in the GenOMICC study ( P =0.004), particularly as the earlier report had displayed evidence of confounding by LD ( P HEIDI = 0.015). 37 Indeed, compared to the analysi
The SOLIDARITY trial, which randomized 2,050 hospitalized COVID-19 patients to IFN beta-1a, found no effect on mortality overall (relative risk [RR]=1.16, 95% CI: 0.96-1.39), but the trial was not powered to evaluate a possible trend across subgroups of COVID-19 severity at randomization (RR=1.40, 95% CI: 0.82-2.40 for those on ventilator, RR=1.13, 95% CI: 0.86-1.50 for those not ventilated but on oxygen, and RR=0.80, 95% CI: 0.27-2.35 in those with neither). 43 The Adaptive COVID-19 Treatment Trial 3 (ACTT-3) stopped enrollmen