Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease.

J Am Coll Cardiol · 2021 · PMC7613585 · PMID 34325833

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highly significantno p-value reported

This proxy SNP (minor allele frequency of 21.0% in CARDIoGRAMplusC4D-UK Biobank) showed highly significant association with CAD in a recent meta-analysis of the CARDIoGRAM and UK Biobank data ( 17 )(n= 547,261) and resulted in a 7.4% (95% CI: 6.0%-8.7%) lower CAD risk (P < 0.0001).

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