Barely Significant
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The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A.

Atherosclerosis · 2022 · PMC7613586 · PMID 35534298

Europe PMCDOI
1
hedged sentence
0.0000
closest p · 0.0× alpha
0.0000
boldest claim

The sentences

highly significantp = 1.05e-27actually significant
However, stratification by isoform into LMW (at least one isoform with 10–22 KIV repeats) and HMW (only isoforms with >22 KIV repeats) carriers, revealed a highly significant decreasing effect of rs41272110 in LMW carriers (β = –24.28, p = 1.05e-27), which was not seen in HMW carriers, where it presented rather a small but significant Lp(a)-increasing effect (β = +1.69, p = 6.13e-07).

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