Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control.

This resulted in similar lists of highly significant top hits, identifying the 4HB-like domains within yeast Zuotin ( Ducett et al., 2013 ; Leidig et al., 2013 ) and its mammalian ortholog Zuotin-related factor 1 (ZRF1), also known as DNAJC2 ( Shrestha et al., 2019 ), as the closest structural relatives ( Figure 6 C; RMSD values: 2.69–3.02 Å, depending on the ortholog and VEL structure).

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