2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca²⁺ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.

In Jurkat T cells expressing G-GECO-Orai1.2 to sense Ca 2+ ions at the mouth of the channel pore, highly significant inhibition by 50 μM STX140 of the initial and sustained Ca 2+ entry phases were observed ( Fig. 2G,H ).

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