Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders.

22 ADDomer-based thermostable vaccines or therapeutics, due to thermostability, could be deployed independent of a cold chain, which is a highly significant criterium given that each year ~50% of vaccine dose wastage is due to cold chain disruptions worldwide. 23 Here, we designed ADDobody, a new scaffold protein based on the crown domain of the PBP ( Figures 1A and 1B ).

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