highly significantp = 0.000
However, more pronounced and highly significant aortic wall thickening in response to VCD/HCD in comparison to chow diet (p = 0.000, p adj =0.000) than in response to HCD alone (p = 0.011, p adj =0.068), suggests that VCDD indeed plays an important role in aortic thickening in the presence of HCD ( Fig. 3A ).