Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.

4B , there are highly significant overlaps between DEGs, DSGs, PRMT5 expression versus the MYCN-157 signature, indicating that the genes which showed altered expression following PRMT5 inhibition, together with PRMT5, had significantly higher expression in MNA neuroblastoma and were co-expressed with the MYCN157 prognostic signature in the SEQC neuroblastoma dataset of 498 tumours.

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