A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration.

Adv Funct Mater · 2026 · PMC7619114 · PMID 42220335

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an increasing trendno p-value reported

[ 22 ] In our hypertrophic SPHs, 14 days of differentiation triggered an almost significantly higher the expression of Col10 at RNA, with an increasing trend for all the patients analyzed.

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almost significantlyno p-value reported

Looking at the expression of hypertrophic genes, at day 28 collagen type 10 ( COL10 ), a hallmark of hypertrophic phenotype, [ 25 ] showed an almost significantly higher expression compared to day 14, suggesting that a two-week differentiation period of SPH in 96-well plates increased its expression but may not be sufficient to reach a fully hypertrophic stage.

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almost significantno p-value reported

Notwithstanding, the expression of other key hypertrophic markers such as RUNX2 and matrix metallopeptidase 13 ( MMP13) showed a significant or almost significant increase, consistent with the progression of the ECO process.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.