Is the Use of BIMA in CABG Sub-Optimal? A Review of the Current Clinical and Economic Evidence Including Innovative Approaches to the Management of Mediastinitis.

23 - 25) The high observance with optimal medical therapy may also have served to reduce the differences in the clinical outcome rates between the two groups, 20) and the high proportion of patients older than 70 years (the benefit of BIMA grafts seems to remain to an approximate age of 69 years at surgery 26) ) with a treatment–age interaction close to significance have all been proposed.

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41) identified six preoperative variables as highly significant independent predictors for the development of mediastinitis: diabetes, obesity, BMI >30 kg/m 2 , chronic obstructive pulmonary disease (COPD), age, and male gender.

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