S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.

rop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY-NC-ND Introduction Hepatoblastoma (HB) is the most common primary malignant tumor of the liver in children, accounting for 80% of pediatric hepatic malignancies and 1% of all malignant tumors in children, with an increasing trend in recent years. 1 , 2 , 3 , 4 , 5 HB is an embryonal tumor, and overactivation of Wnt/β-catenin, hedgehog, and phosphatidylinositol 3-kinase (PI3K)/Akt signaling has been reported to be associated with its development. 5 , 6 , 7 , 8 , 9 Recent progress in research and development of comprehensive

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