HLA-J, a Non-Pseudogene as a New Prognostic Marker for Therapy Response and Survival in Breast Cancer.

Geburtshilfe Frauenheilkd · 2020 · PMC7647720 · PMID 33173240

Europe PMC DOI

hedged sentences

0.0056

closest p · 0.1× alpha

0.0501

boldest claim

The sentences

highly significantp = 0.0056actually significant

In contrast, for HLA-J mRNA there was a highly significant negative association between HLA-J mRNA expression levels and tumor regression grade (ρ: − 0.6094, p = 0.0056).

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a trend towards significancep = 0.0501so close (0.05 < p ≤ 0.1)

4 non-parametric Spearman rank correlation indicated a positive, statistically significant association between mRNA-expression measured by RT-qPCR in chemotherapy naïve, fresh core needle biopsy tissue between HLA-J and ESR1 mRNA status adjusted to IHC positivity (ρ: 0.5879, p = 0.009) as well as between HLA-J and KRT5 (ρ: 0.6121, p = 0.0041) and a trend towards significance between HLA-J and continuous ESR1 mRNA levels (ρ: 0.4436, p = 0.0501).

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