HDMTX-based induction therapy followed by consolidation with conventional systemic chemotherapy and intraventricular therapy (modified Bonn protocol) in primary CNS lymphoma: a monocentric retrospective analysis.

Neurol Res Pract · 2019 · PMC7650117 · PMID 33324883

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almost significantno p-value reported

Comparing the results achieved with intrathecal therapies in patients < 65 years, our data suggest a higher efficacy of intraventricular therapy than of intrathecal liposomal AraC: On univariate analysis, an almost significant PFS difference was found benefitting intraventricular therapy with a HR of 0.46 (0.21–1.02), whereas the HR for OS was 0.53 (0.19–1.47).

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