HbF Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines.

Remarkably, this revealed that, despite the relatively low r 2 for each individual chemokine, a highly significant ( p = 0.0008), four-chemokine model including CCL17 (TARC), CCL11 (Eotaxin), CCL2 (MCP-1), and PDGF-BB could explain about 80% of the variation in the proportion of HMC/CD34 in our cohort of SCD and healthy individuals ( Figure 4 B).

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